JPH0222075B2 - - Google Patents

Info

Publication number
JPH0222075B2
JPH0222075B2 JP55106412A JP10641280A JPH0222075B2 JP H0222075 B2 JPH0222075 B2 JP H0222075B2 JP 55106412 A JP55106412 A JP 55106412A JP 10641280 A JP10641280 A JP 10641280A JP H0222075 B2 JPH0222075 B2 JP H0222075B2
Authority
JP
Japan
Prior art keywords
cyclohexyl
formula
adenine
cyclohexenyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP55106412A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57163382A (en
Inventor
Takayuki Naito
Susumu Nakagawa
Tetsuo Yamazaki
Takaaki Okita
Akihiro Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BURISUTORU MAIYAAZU KENKYUSHO KK
Original Assignee
BURISUTORU MAIYAAZU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BURISUTORU MAIYAAZU KENKYUSHO KK filed Critical BURISUTORU MAIYAAZU KENKYUSHO KK
Publication of JPS57163382A publication Critical patent/JPS57163382A/ja
Publication of JPH0222075B2 publication Critical patent/JPH0222075B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP55106412A 1979-08-06 1980-08-04 Purine bronchodilator Granted JPS57163382A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/064,240 US4241063A (en) 1979-08-06 1979-08-06 Purine derivatives and their use as bronchodilators

Publications (2)

Publication Number Publication Date
JPS57163382A JPS57163382A (en) 1982-10-07
JPH0222075B2 true JPH0222075B2 (en]) 1990-05-17

Family

ID=22054538

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55106412A Granted JPS57163382A (en) 1979-08-06 1980-08-04 Purine bronchodilator

Country Status (5)

Country Link
US (1) US4241063A (en])
JP (1) JPS57163382A (en])
AU (1) AU520583B2 (en])
BE (1) BE884653A (en])
ZA (1) ZA804701B (en])

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743689A (en) * 1984-11-20 1988-05-10 Nippon Kayaku Kabushiki Kaisha Antibiotic derivative of adenine
DE3529497A1 (de) * 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
JPH01501478A (ja) * 1986-11-25 1989-05-25 インスティテュト　オルガニチェスコゴ　シンテザ　アカデミイ　ナウク　ラトビイスコイ　エスエスアール ９―置換グアニン
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5736549A (en) * 1994-10-05 1998-04-07 Chiroscience Limited Hypoxanthine and guanine compounds
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US6294541B1 (en) 1996-06-06 2001-09-25 Euro-Celtique S.A. Purine derivatives having phosphodiesterase IV inhibition activity
WO1999031103A1 (en) 1997-12-12 1999-06-24 Euro-Celtique S.A. Preparation of 3-substituted adenines
US6319928B1 (en) 1998-11-30 2001-11-20 Euro-Celtique, S.A. Purine derivatives having phosphodiesterase IV inhibition activity
CN1377353A (zh) 1999-04-02 2002-10-30 欧罗赛铁克股份有限公司 具有磷酸二酯酶iv抑制活性的嘌呤衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228937A (en) * 1963-07-17 1966-01-11 Shell Oil Co Adenine derivative
US3930005A (en) * 1973-06-15 1975-12-30 Squibb & Sons Inc Antiinflammatory agents and their use
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
US3917837A (en) * 1974-10-21 1975-11-04 American Cyanamid Co Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
JPS5271492A (en) * 1975-12-10 1977-06-14 Kohjin Co Ltd Synthesis of 9-substituted-2-substituted thioadenines

Also Published As

Publication number Publication date
AU6102180A (en) 1981-02-12
US4241063A (en) 1980-12-23
BE884653A (fr) 1981-02-06
AU520583B2 (en) 1982-02-11
JPS57163382A (en) 1982-10-07
ZA804701B (en) 1981-10-28

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